JH-II-127

CAT: 0026-9632-25Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0026-9632-25Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

JH-II-127 is a highly potent, selective, and cell-permeable LRRK2 inhibitor, with IC₅₀ of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T. JH-II-127 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 μM in a variety of cell types and is capable of inhibiting Ser935 phosphorylation in mouse brain following oral delivery of doses as low as 30 mg/kg.

Shipping Conditions

gel pack

Storage Conditions

-20°C

Shelf Life

36 months

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BA3686-50	JH-II-127
A15777-25	JH-II-127 25mg
A15777-100	JH-II-127 100mg
A15777-10	JH-II-127 10mg
A15777-5	JH-II-127 5mg
A15777-50	JH-II-127 50mg
A15777-1	JH-II-127 1mg
6289/10	JH-II-127 10 mg
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JH-II-127

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