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BMS-833923

CAT: 0026-9547-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-9547-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMS-833923 is a potent inhibitor of Smo (Smoothened) with potential antineoplastic activity. It blocks binding of BODIPY cyclopamine (IC₅₀ = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC₅₀s = 6-35 nM). BMS-833923 inhibits Shh pathway activity and prevents tumor growth in medulloblastoma and pancreatic carcinoma xenograft models.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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