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Zotarolimus

CAT: 0026-9530-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-9530-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Zotarolimus is a semi-synthetic derivative of Sirolimus (Cat. No. 1568) that acts as an immunosuppressant. Zotarolimus displays meachanism similar to sirolimus in having high-affinity binding to the immunophilin FKBP12 and comparable potency for inhibiting in vitro proliferation of both human and rat T cells. In vitro, zotarolimus inhibited FKBP-12 binding (IC50 = 2.8 nM) and potently blocked smooth muscle cell (IC₅₀ = 2.9 nM) and endothelial cell (IC₅₀ = 2.6 nM) proliferation.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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