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SU-5416

CAT: 0026-9491-25Size: 25 mgDry Ice: NoHazardous: No
CAT#:0026-9491-25Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SU-5416 is a potent tyrosine kinase inhibitor best known as an inhibitor of the vascular endothelial growth factor receptor (VEGFR-2; Flk-1/KDR). In addition to inhibiting VEGFR-2 (IC₅₀ = 1 μM), SU-5416 also inhibits PDGFR (IC₅₀ = 20 μM), c-Kit (IC₅₀ = 30 nM), RET (IC₅₀ = 170 nM), Flt-3 (IC₅₀ = 160 nM), ABL (IC₅₀ = 11 μM), and ALK (IC₅₀ = 1.2 μM).SU 5416 does not inhibit epidermal growth factor (EGFR) or fibroblast growth factor receptor (FGFR) tyrosine kinases (IC₅₀ > 100 μM). Acts as a suppressor of tumor vascularization, preventing the growth of multiple tumor types.
Shipping Conditions
Gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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