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CPI-613

CAT: 0026-9464-10Size: 10 mgDry Ice: NoHazardous: No
CAT#:0026-9464-10Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CPI-613 is a non-redox active lipoate derivative that acts as a selective inhibitor mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase. In vitro, CPI-613 dose-dependently and efficiently kills H460 human lung cancer cells and Saos-2 human sarcoma cells. In vitro, CPI-613 treatment potently disrupts H460 cancer cell mitochondrial metabolism including inhibition of PDH complex activity. CPI-613 treatment also leads to loss of mitochondrial membrane potential as assessed by JC-1 mitochondrial uptake. CPI-613 also induces apoptotic and non-apoptotic cell death in the cells of H460 human lung cancer and Saos-2 human sarcoma in vitro.
Shipping Conditions
Gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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Alternative Products

CatalogName
MBS384559-01CPI-613
163207CPI 613
A11786-25CPI-613 25mg
A11786-50CPI-613 50mg
S2776-50mgDevimistat (CPI-613)
A11786-5CPI-613 5mg
A11786-10CPI-613 10mg
A11786-100CPI-613 (Devimistat) 100mg
A11786-500CPI-613 (Devimistat) 500mg
A11786-10mM-DCPI-613 10mM * 1mL in DMSO

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