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CCG-1423

CAT: 0026-9434-25Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0026-9434-25Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCG-1423 is a specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription. CCG-1423 displays activity in several in vitro cancer cell functional assays. CCG-1423 potently (<1 mumol/L) inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells, and whereas it inhibits the growth of RhoC-overexpressing melanoma lines at nanomolar concentrations, it is less active on related lines that express lower levels of Rho. Similarly, CCG-1423 selectively stimulates apoptosis of the metastasis-prone, RhoC-overexpressing melanoma cell line (A375M2) compared with the parental cell line (A375).
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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