DMXAA

CAT: 0026-2804-25Size: 25 mgDry Ice: NoHazardous: No
CAT#:0026-2804-25Size:25 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DMXAA acts as a tumor vascular disrupting agent, inducing apoptosis in tumor vascular endothelium resulting in necrosis at the tumor core. It potently activates the TANK-binding kinase 1-interferon regulatory factor 3 signaling pathway in leukocytes, inducing type-I-interferon production. In addition, DMXAA significantly inhibits several kinases in endothelial cells, including the vascular endothelial growth factor (VEGF) receptors VEGFR1 and VEGFR2 (IC₅₀ = 119 and 11 µM, respectively). Recent studies have shown that DMXAA is a competitive agonist ligand for mouse.
Shipping Conditions
Gel Pack
Storage Conditions
-20°C
Shelf Life
36 months

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