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Apoptosis activator 2

CAT: 0026-2784-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-2784-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Apoptosis activator 2 is a cell-permeable apoptosis activator that promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC₅₀ > 40 μM).
Shipping Conditions
Gel Pack
Storage Conditions
-20°C
Shelf Life
36 months