N-Myc Antibody

CAT: 0013-GTR18574889Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0013-GTR18574889Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

The v-Myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas, and belongs to a family of oncogenes conserved throughout evolution. In humans, the family consists of five genes: c-Myc, N-Myc, R-Myc, L-Myc and B-Myc. Amplification of the N-Myc gene has been found in human neuroblastomas and cell lines. Its amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-Myc gene encodes a nuclear phosphoprotein that exhibits relatively short (30 min) half life in vivo. The prototype member of the family, c-Myc p67, binds DNA in a sequence-specific manner subsequent to dimerization with a second basic region helix-loop-helix leucine zipper motif protein, designated Max.

UniProt

P04198

Reactivity

Human, Mouse, Rat

Immunogen

A recombinant full-length human n-Myc protein was used as the immunogen for the n-Myc antibody.

Clonality

Monoclonal

Clone

NMYC-1

Conjugation

Unconjugated

Field of Research

Cancer Biology

Purification

Protein G affinity chromatography

Dilution

Immunofluorescence: 1-2ug/ml, Western blot: 1-2ug/ml

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the n-Myc antibody should be determined by the researcher.

Tested Applications

IF, WB

Host or Source

Mouse

Preservative

1 mg/ml in 1X PBS; rAlbumin free, sodium azide free

Isotype

Mouse IgG2a, kappa

UniProtKB · P04198

N-myc proto-oncogene protein

MYCN_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P04198
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: MYCN
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q53XS5, Q6LDT9

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-binding

Disease

Disease variantProto-oncogene

Cellular component

Nucleus

PTM

Phosphoprotein

Biological process

TranscriptionTranscription regulation

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