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LY364947

CAT: 0026-2646-1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0026-2646-1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY364947 is a selective inhibitor of TGF-β RI (TGFR-I, TβR-I, ALK-5), with an IC₅₀ value of 59 nM. LY364947 only weakly inhibits TGF-β RII (IC₅₀ = 400 nM), p38 MAPK (IC₅₀ = 740 nM), and mixed lineage kinase-7 (MLK-7; IC₅₀ = 1,400 nM).It inhibits TGF-β-induced cell growth (IC₅₀ = 89 nM) in NIH 3T3 mouse fibroblasts and TGF-β-directed Smad phosphorylation, synthesis of fibronectin, PAI-1 and uPA protein, and matrigel invasion in MDA-MB-231 cells.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
48 months

Alternative Products

CatalogName
B2287-25LY364947
A13446-500LY364947 500mg
A13446-100LY364947 100mg
A13446-5LY364947 5mg
A13446-200LY364947 200mg
A13446-50LY364947 50mg
A13446-25LY364947 25mg
A13446-10LY364947 10mg
A13446-10mM-DLY364947 10mM * 1mL in DMSO

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