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JW55

CAT: 0026-2612-25Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0026-2612-25Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JW55 is a small molecule inhibitor of the Wnt/β-catenin signaling pathway that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2), regulators of the β-catenin destruction complex. Inhibition of TNKS1/2 poly(ADP-ribosyl)ation activity by JW55 leads to stabilization of AXIN2, a member of the β-catenin destruction complex, followed by increased degradation of β-catenin. In a dose-dependent manner, JW55 inhibits canonical Wnt signaling in colon carcinoma cells that contained mutations in either the APC (adenomatous polyposis coli) locus or in an allele of β-catenin.
Shipping Conditions
Gel pack
Storage Conditions
-20 ̊C
Shelf Life
36 months

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CatalogName
C12173-25mgJW55
PBB99353-01Tankyrase1/2 Inhibitor IV, JW55

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