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Myriocin (ISP-1)

CAT: 0026-2567-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-2567-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A fungal metabolite with potent immunosuppressant activity that is 10-100 fold more compared to Cyclosporin A (Cat. No. 1522). It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide. It was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2/M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip1) expression.
Shipping Conditions
Gel pack
Storage Conditions
-20°C
Shelf Life
24 months

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