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Apigenin

CAT: 0026-2508-25Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0026-2508-25Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A naturally occurring plant flavone that displays remarkable anti-inflammatory, antioxidant and anti-carcinogenic properties. It selectively inhibits casein kinase II (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC₅₀ value of 30 µM to improve renal function in a rat model of glomerulonephritis. CK2 inhibition by 20 µM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI 231 cells. At 5 µM, it is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.
Shipping Conditions
Gel pack
Storage Conditions
-20°C
Shelf Life
24 months

Alternative Products

CatalogName
N1828-5.1Apigenin

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