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TPCA-1

CAT: 0026-2431-25Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0026-2431-25Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent and selective inhibitor of IκB kinase-2 (IKK-2) (IC₅₀ = 17.9 nM). Displays > 22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes. TPCA-1 inhibits production of pro-inflammatory cytokines in vitro and in vivo and inhibits NF-κB nuclear localization. It has been used to study inhibition of IKK-2 to prevent inflammatory mediator release in animal models of arthritis and airway inflammation.
Shipping Conditions
gel pack
Storage Conditions
-20 ̊C
Shelf Life
36 months

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A4602-5.1TPCA-1

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