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AZD8055

CAT: 0026-2340-1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0026-2340-1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, ATP-competitive inhibitor of mTOR kinase (both mTORC1 and mTORC2) with an IC₅₀ of 0.8 nM. AZD8055 displays excellent selectivity (~ 1,000-fold) against all class I PI3K isoforms and other members of the PI3K-like kinase family. In addition, it shows no significant activity against a panel of 260 kinases at concentrations up to 10 µM. AZD8055 inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream proteins.
Shipping Conditions
gel pack
Storage Conditions
-20 ̊C
Shelf Life
36 months

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