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Manumycin A

CAT: 0026-2333-5Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0026-2333-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
An antibiotic Isolated from Streptomyces parvulus. A Potent, selective and competitive cell permeable rasfarnesyltransferase (FTase) inhibitor (IC₅₀ = 30 nM). Does not affect geranylgeranyltransferase (GGTase) (IC₅₀ = 180 µM). Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19 µM).µM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras.
Shipping Conditions
gel pack
Storage Conditions
-20 ̊C
Shelf Life
36 months

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