GSK126

CAT: 0026-2282-5Size: 5 mgDry Ice: NoHazardous: No
CAT#:0026-2282-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, highly selective, S-adenosyl-methionine(SAM)-competitive, small-molecule inhibitor of EZH2 methyltransferase activity. GSK126 is highly selective against other methyltransferases and multiple other protein classes, even 150-fold more selective for the closest EZH1 (Kiapp = 89 nM) and more than 1,000-fold selective for 20 other human methyltransferases, including both SET-domain-containing and non-SET domain-containing methyltransferases. It decreases global H3K27me3 levels and reactivates silenced polycomb repressive complex 2 (PRC2) target genes.
Shipping Conditions
gel pack
Storage Conditions
-20 ̊C
Shelf Life
36 months

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CatalogName
A3446-5GSK126

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