PYR-41

CAT: 0026-1925-25Size: 25 mgDry Ice: NoHazardous: No
CAT#:0026-1925-25Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cell-permeable. An irreversible ubiquitin-activating enzyme (E1) inhibitor (IC₅₀ < 10 μM). Blocks ubiquitylation and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-κB activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

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