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Sunitinib Malate (Sutent)

CAT: 0026-1611-1000Size: 1 gDry Ice: NoHazardous: No
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CAT#:0026-1611-1000Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sunitinib is a potent inhibitor of CSF-1 receptor kinase in an enzyme assay, with an IC₅₀ of 7 nM, and inhibits receptor phosphorylation in a cellular assay with an IC₅₀ of 61 nM. Sunitinib inhibits SCF-induced phosphotyrosine levels on KIT (IC₅₀ = 1 - 10 nM) and reduced SCF-stimulated ERK1/2 phosphorylation with an IC₅₀ value consistent with that for inhibition of KIT phosphotyrosine levels. Sunitinib also inhibited SCF-stimulated proliferation in NCI-H526 cells (IC₅₀ = 2 nM).
Shipping Conditions
RT
Storage Conditions
-20°C
Shelf Life
24months

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