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Cathepsin E Inhibitor Screening Kit (Fluorometric)

CAT: 0026-K166-100Size: 100 AssaysDry Ice: NoHazardous: No
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CAT#:0026-K166-100Size:100 Assays
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cathepsin E (CTSE, EC: 3.4.23.34) is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that is found in highest concentration on the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of the gastric cancers. BioVision’s Cathepsin E Inhibitor Screening Kit utilizes the ability of Cathepsin E to cleave a synthetic MCA-based peptide substrate to release free MCA, which can be easily quantified using a fluorometer or fluorescence microplate reader. In the presence of a Cathepsin E-specific inhibitor, the cleavage of the substrate is reduced/abolished resulting in decrease or total loss of the MCA fluorescence. This simple and high-throughput adaptable assay kit can be used to screen/study/characterize the potential inhibitors of Cathepsin E.
Applications
Screen/study/characterize potential inhibitors of Cathepsin E
Detection Method
Fluorescence (Ex/Em = 320/420 nm)
Features & Benefits
• Convenient & Rapid • High-throughput adaptable assay to screen/study/characterize the potential inhibitors of Cathepsin E • Cathepsin E inhibitor is included in the kit
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
12 months

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