BioSim™ anti-Nivolumab (Opdivo®) (Human) ELISA Kit

BioSim™ anti-Nivolumab (Opdivo®) (Human) ELISA Kit

• Description: Nivolumab (Opdivo®) is a human immunoglobulin G4 (IgG4) monoclonal antibody that binds to the programmed cell death 1 (PD-1) receptor and selectively blocks interaction with its programmed death ligands PD-L1 and PD-L2. Upregulation of PD-1 ligands occurs in some tumors and signalling through this pathway can contribute to inhibition of active T-cell immune surveillance of tumour tissue. The inhibitory effect of PD-1 and its ligands occurs through the promotion of apoptosis in antigen specific T cells while simultaneously blocking apoptosis in suppressor T cells. Blocking PD-1 activity has been shown to lead to decreased tumour growth in mouse tumour models. However, some patients develop unwanted immunogenicity, which leads to production of anti-drug-antibodies (ADAs) inactivating the therapeutic effects of the treatment and, in rare cases, inducing adverse effects. BioVision’s BioSimTM anti-Nivolumab ELISA kit is designed to detect antibody against Nivolumab with high specificity and sensitivity in biological matrices.
• CAS Number: 7732-18-5
• Reactivity: Human
• Applications: This ELISA kit is used for Qualitative determination of antibody against Nivolumab (Opdivo) in serum and plasma
• Detection Method: Absorbance (450 nm)
• Features & Benefits: Easy, convenient, sensitive and time-saving method toqualitative determination of antibody against Nivolumab (Opdivo) in human serum and plasma. Cross Reactivity: Nivolumab (Opdivo®) infusion camouflages/masks the presence of antibody to Nivolumab (ATN) in serum/plasma samples. Therefore, blood sampling time is critical for detection of ATN. It is convenient to obtain blood sample just before the infusion or at least 2 weeks after the infusion of Nivolumab.
• Shipping Conditions: gel pack
• Storage Conditions: 4°C
• Shelf Life: 12 months