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MCM6 Antibody

CAT: 0013-GTR18574872Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18574872Size:100 µg
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Description
The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM6 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1/S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the post-replicative state of the cell. MCM2/MCM6 complexes function as substrates for Cdc2/cyclin B in vitro.
UniProt
Q14566
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 228-368) was used as the immunogen for this MCM6 antibody.
Clonality
Monoclonal
Clone
MCM6/2999
Conjugation
Unconjugated
Purification
Protein G affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml, Western blot: 2-4ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the MCM6 antibody should be determined by the researcher.
Tested Applications
IHC-P, WB
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2b, kappa

UniProtKB · Q14566

DNA replication licensing factor MCM6

MCM6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q14566
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MCM6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.6.4.12
Processing
—
Secondary accessions
B2R6H2, Q13504, Q99859
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationGlycoproteinPhosphoprotein

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycleDNA replication

Cellular component

ChromosomeNucleus

Molecular function

DNA-bindingHelicaseHydrolase

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