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Steviol

CAT: 0804-HY-N2057-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2057-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Steviol is the main metabolite of steviol glycosides and an inhibitor of AQP2/CFTR. Steviol slows down the growth of renal cysts by inhibiting the activity of CFTR, reducing the expression of AQP2, and promoting the degradation of AQP2 and CFTR. Steviol can be used in the research of polycystic kidney disease[1][2].
CAS Number
471-80-7
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Aquaporin; CFTR; Chloride Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/steviol.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@]1(C(O)=O)CCC[C@@]2(C)[C@@]3([H])[C@@]4(CC([C@@](CC3)(O)C4)=C)CC[C@]12[H]
Molecular Formula
C20H30O3
Molecular Weight
318.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Noitem R, et al. Steviol slows renal cyst growth by reducing AQP2 expression and promoting AQP2 degradation. Biomed Pharmacother. 2018 May;101:754-762.|[2]Melis MS, et al. Steviol effect, a glycoside of Stevia rebaudiana, on glucose clearances in rats. Braz J Biol. 2009 May;69 (2) :371-4.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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