Products for Research Use Only
RegisterLogin

RBC8

CAT: 0804-HY-12873-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-12873-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
RBC8 is a selective and allosteric RALA and RALB inhibitor. RBC8 stabilizes the inactive GDP-bound state of Ral, preventing its activation. RBC8 promotes the phosphorylation of proteins related to the MAPK/JNK pathway. RBC8 has the activity of inhibiting tumor cell proliferation, migration and invasion. RBC8 is used in the study of various cancers such as lung cancer, gastric cancer, and multiple myeloma[1][2][3].
CAS Number
361185-42-4
UNSPSC
12352005
Hazard Statement
H302
Target
JNK; p38 MAPK; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RBC8.html
Purity
98.0
Solubility
DMSO : ≥ 40 mg/mL
Smiles
N#CC(C1C2=CC(OC)=CC=C2OC)=C(N)OC3=C1C(C4=CC=C5C=CC=CC5=C4)=NN3
Molecular Formula
C25H20N4O3
Molecular Weight
424.45
Precautions
H302
References & Citations
[1]Yan C, et al. Discovery and characterization of small molecules that target the GTPase Ral. Nature. 2014 Nov 20;515 (7527) :443-7.|[2]Seibold M, et al. RAL GTPases mediate multiple myeloma cell survival and are activated independently of oncogenic RAS. Haematologica. 2020 Sep 1;105 (9) :2316-2326.|[3]Wang P, et al. RCC2 Interacts with Small GTPase RalA and Regulates Cell Proliferation and Motility in Gastric Cancer. Onco Targets Ther. 2020 Apr 14;13:3093-3103.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-125987-01RBC6
HY-154921ALactosylceramide (porcine RBC)
HY-165163-01Globotetraosylceramide (porcine RBC)
HY-149125Globotriaosylceramide (porcine RBC)

Alternative Products

CatalogName
B4884-50RBC8
A16681-100RBC8 100mg
A16681-50RBC8 50mg

Popular Products