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AStAx-35R

CAT: 0804-HY-P10392Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P10392Size:1 Each
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Description
AStAx-35R, a stapled peptide, antagonizes nuclear form of β-catenin and inhibits Wnt signaling. aStAx-35R inhibits competitively the binding of β-catenin to TCF4. aStAx-35R selectively induces growth inhibition of Wnt-dependent cancer cells[1].
CAS Number
1418863-17-8
UNSPSC
12352209
Target
Wnt; β-catenin
Type
Peptides
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/astax-35r.html
Smiles
O=C([C@H](CCCNC(N)=N)NC(C)=O)N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N3CCC[C@H]3C(N[C@@H](CCCNC(N)=N)C(N[C@](C)(C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@H]4CC(O)=O)=O)=O)=O)CCC/C=C/CCC[C@@](C)(C(N[C@@H](CC5=CN=CN5)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC6=CNC7=C6C=CC=C7)C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)=O)=O)NC4=O)=O)=O)=O)=O
Molecular Formula
C111H178N40O20
Molecular Weight
2392.86
References & Citations
[1]Grossmann TN, et al. Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin. Proc Natl Acad Sci U S A. 2012 Oct 30;109 (44) :17942-7.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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