N-Myristoyl-Lys-Arg-Thr-Leu-Arg

• UNSPSC Description:

  N-Myristoyl-Lys-Arg-Thr-Leu-Arg is a protein kinase C (PKC) inhibitor with an IC50 value of 75 μM. N-Myristoyl-Lys-Arg-Thr-Leu-Arg inhibits IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat[1].

• Target Antigen:

  PKC

• Type:

  Peptides

• Related Pathways:

  Epigenetics;TGF-beta/Smad

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/n-myristoyl-lys-arg-thr-leu-arg.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)[C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC(CCCCCCCCCCCCC)=O)=O

• Molecular Weight:

  883.18

• References & Citations:

  [1]Ioannides CG, et, al. Inhibition of IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat by a novel peptide inhibitor of protein kinase C. Cell Immunol. 1990 Nov;131(1):242-52.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  125678-68-4