Cirsiliol

• Description:

  Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Lipoxygenase

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Cirsiliol.html

• Purity:

  99.19

• Solubility:

  DMSO : ≥ 25 mg/mL

• Smiles:

  O=C1C=C (C2=CC=C (O) C (O) =C2) OC3=CC (OC) =C (OC) C (O) =C13

• Molecular Formula:

  C17H14O7

• Molecular Weight:

  330.29

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Mustafa EH, et al. Effects of cirsiliol, a flavone isolated from Achillea fragrantissima, on rat isolated ileum. Gen Pharmacol. 1992 May;23 (3) :555-60.|[2]Kang J, et al. Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines. J Biol Chem. 2013 Sep 20;288 (38) :27343-57.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  5-LOX

• CAS Number:

  34334-69-5