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CD1530

CAT: 0804-HY-108527-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108527-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD1530 is an orally active, selective RARγ agonist and antibacterial agent. CD1530 reduces Smad1/5/8 phosphorylation and overall Smad levels. CD1530 reduces β-catenin, MMP9 protein, and ROS levels. CD1530 exhibits activities such as inhibiting heterotopic ossification, promoting Achilles tendon healing, and inhibiting muscle fatty infiltration. CD1530 can be used in the research of orthopedic diseases (such as heterotopic ossification, Achilles tendon injury), muscle diseases (such as muscle fatty infiltration-related diseases) [1][2][3][4][5][6].
CAS Number
107430-66-0
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Bacterial; MMP; RAR/RXR; Reactive Oxygen Species (ROS) ; TGF-beta/Smad; β-catenin
Type
Reference compound
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt; TGF-beta/Smad; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Infection; Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cd1530.html
Purity
98.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=C(C2=CC=C3C=C(O)C(C4(C5)CC6CC5CC(C6)C4)=CC3=C2)C=C1
Molecular Formula
C27H26O3
Molecular Weight
398.49
Precautions
H315, H319, H335
References & Citations
[1]Shimono K, et al. Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists. Nat Med. 2011 Apr;17 (4) :454-60.|[2]Murholm M, et al. Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes. BMC Cell Biol. 2013 Sep 23;14:41.|[3]Tang XH, et al. Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Proc Natl Acad Sci U S A. 2014 Jun 17;111 (24) :8907-12.|[4]Yimiti D, et al. CD1530, selective RARγ agonist, facilitates Achilles tendon healing by modulating the healing environment including less chondrification in a mouse model. J Orthop Res. 2025 Feb;43 (2) :273-284.|[5]Kim W, et al. A new class of synthetic retinoid antibiotics effective against bacterial persisters. Nature. 2018 Apr 5;556 (7699) :103-107.|[6]Shirasawa H, et al. Retinoic Acid Receptor Agonists Suppress Muscle Fatty Infiltration in Mice. Am J Sports Med. 2021 Feb;49 (2) :332-339.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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