RH01386

• Description :

  RH01386 is a small molecule that can prevent endoplasmic reticulum stress (ERS) -induced β cell dysfunction and death, and inhibits proapoptotic gene expression. RH01386 restores ERS-impaired glucose-stimulated insulin secretion responses. RH01386 has the potential for type 2 diabetes treatment[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/rh01386.html

• Purity :

  99.76

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  N#CC1=C(C2CCCCC2)N=C(SC3=CC=C(C(F)(F)F)C=C3[N+]([O-])=O)NC1=O

• Molecular Formula :

  C18H15F3N4O3S

• Molecular Weight :

  424.40

• References & Citations :

  [1]Tran K, et al. Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death.ACS Chem Biol. 2014 Dec 19;9 (12) :2796-806.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [301177-36-6]