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RH01386

CAT: 0804-HY-124771-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
CAT#:0804-HY-124771-01Size:10 mM - 1 mL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RH01386 is a small molecule that can prevent endoplasmic reticulum stress (ERS) -induced β cell dysfunction and death, and inhibits proapoptotic gene expression. RH01386 restores ERS-impaired glucose-stimulated insulin secretion responses. RH01386 has the potential for type 2 diabetes treatment[1].
CAS Number
[301177-36-6]
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/rh01386.html
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=C(C2CCCCC2)N=C(SC3=CC=C(C(F)(F)F)C=C3[N+]([O-])=O)NC1=O
Molecular Formula
C18H15F3N4O3S
Molecular Weight
424.40
References & Citations
[1]Tran K, et al. Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death.ACS Chem Biol. 2014 Dec 19;9 (12) :2796-806.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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