DNase I, Bovine pancreas

• UNSPSC Description:

  DNase I (EC 3.1.21.1) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer[1].

• Target Antigen:

  Others

• Type:

  Enzyme

• Related Pathways:

  Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/dnase-i-bovine-pancreas.html

• Solubility:

  DMSO : 43.48 mg/mL (adjust pH to 3 with 1M HCl)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  [DNase I, Bovine pancreas]

• References & Citations:

  [1]Lauková L, et al. Deoxyribonucleases and Their Applications in Biomedicine. Biomolecules. 2020 Jul 11;10(7):1036.|[2]Sugihara S, et al. Deoxyribonuclease treatment prevents blood-borne liver metastasis of cutaneously transplanted tumour cells in mice. Br J Cancer. 1993 Jan;67(1):66-70.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20°C for 2 years

• Clinical Information:

  Launched

• CAS Number:

  9003-98-9