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Orobol

CAT: 0804-HY-N3127-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N3127-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC50=1.24-4.45 μM) . Orobol also inhibits PI3K isoforms (IC50=3.46-5.27 μM for PI3K α/β/γ/K/δ) [1][2].
CAS Number
480-23-9
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Casein Kinase; PI3K; VEGFR
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/orobol.html
Purity
99.74
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C2=C(O)C=C(O)C=C2OC=C1C3=CC(O)=C(O)C=C3
Molecular Formula
C15H10O6
Molecular Weight
286.24
Precautions
H302, H312, H332
References & Citations
[1]Kim MH, et al. Lipid Nanoparticles for Enhancing the Physicochemical Stability and Topical Skin Delivery of Orobol. Pharmaceutics. 2020;12 (9) :845. Published 2020 Sep 3.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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