Hydroxy-PEG4-acid

• Description :

  Hydroxy-PEG4-acid is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Hydroxy-PEG4-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

• Product Name Alternative :

  2-APV; DL-2-Amino-5-phosphonovaleric acid

• UNSPSC :

  12352203

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  ADC Linker; PROTAC Linkers

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/hydroxy-peg4-acid.html

• Purity :

  99.81

• Solubility :

  DMSO : 200 mg/mL (ultrasonic) |Ethanol : ≥ 200 mg/mL

• Smiles :

  OC(CCOCCOCCOCCOCCO)=O

• Molecular Formula :

  C11H22O7

• Molecular Weight :

  266.29

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Tinya Abrams, et al. Antibody drug conjugates. WO2016203432A1.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Non-cleavable Linker; PEG Linkers

• CAS Number :

  [937188-59-5]