Androgen Receptor Antibody

CAT: 0013-GTR18574044Size: 7 mLDry Ice: NoHazardous: No

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CAT#:0013-GTR18574044Size:7 mL

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Description

The Androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. [RefSeq]

UniProt

P10275

Reactivity

Human

Immunogen

Recombinant full-length human AR protein was used as the immunogen for the Androgen Receptor antibody.

Clonality

Monoclonal

Clone

ANDRC-1

Conjugation

Unconjugated

Purification

Protein G affinity chromatography

Dilution

The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the Androgen Receptor antibody should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 min.2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Tested Applications

IHC-P

Host or Source

Mouse

Preservative

Prediluted in 1X PBS, 0.1 mg/ml rAlbumin, 0.05% sodium azide; For IHC use only

Isotype

Mouse IgG1, kappa

UniProtKB · P10275

Androgen receptor

ANDR_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P10275
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: AR
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: A0A0B4J1T2, A2RUN2, B1AKD7, C0JKD3, C0JKD4, E7EVX6, Q9UD95

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDNA-bindingReceptor

Coding sequence diversity

Alternative splicingTriplet repeat expansion

Cellular component

CytoplasmNucleus

Disease

Disease variantNeurodegenerationPseudohermaphroditism

PTM

Isopeptide bondLipoproteinPalmitatePhosphoproteinUbl conjugation

Ligand

Lipid-bindingMetal-bindingSteroid-bindingZinc

Biological process

TranscriptionTranscription regulation

Domain

Zinc-finger

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Alternative Products

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70R-32757	Androgen Receptor antibody
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