Products for Research Use Only
RegisterLogin

ZAP70 Antibody

CAT: 0013-GTR18573819Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR18573819Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
UniProt
P43403
Reactivity
Human
Immunogen
A portion of amino acids 247-382 from the human protein was used as the immunogen for the ZAP70 antibody.
Clonality
Monoclonal
Clone
ZAP70/2035
Conjugation
Unconjugated
Field of Research
Signal Transduction
Purification
Protein G affinity chromatography
Dilution
Flow cytometry: 1-2ug/10^6 cells, Immunofluorescence: 1-2ug/ml, ELISA: 2-4ug/ml (order BSA/azide-free format), Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the ZAP70 antibody should be determined by the researcher.
Tested Applications
ELISA, FACS, IF, IHC-P
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG1, kappa

UniProtKB · P43403

Tyrosine-protein kinase ZAP-70

ZAP70_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P43403
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ZAP70
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.2
Processing
—
Secondary accessions
A6NFP4, Q6PIA4, Q8IXD6, Q9UBS6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Biological process

Adaptive immunityImmunity

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCytoplasmMembrane

Disease

Disease variantSCID

Molecular function

KinaseTransferaseTyrosine-protein kinase

Domain

RepeatSH2 domain

Related Products

CatalogName
GTR18272143ZAP70 Conjugated Antibody
GTR18290951-01ZAP70 monoclonal antibody
GTR18047747-01ZAP70 monoclonal antibody
GTR18291046-01ZAP70 monoclonal antibody
GTR18283560ZAP70 Conjugated Antibody
GTR18212662-01ZAP70 monoclonal antibody
GTR18300670-01ZAP70 polyclonal antibody
GTR18298524-01ZAP70 monoclonal antibody
GTR18044910-01ZAP70 polyclonal antibody
GTR18212618-01ZAP70 monoclonal antibody

Alternative Products

CatalogName
70R-50565ZAP70 antibody

Popular Products