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Recombinant TIMP1 Antibody

CAT: 0013-GTR18573527Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18573527Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TIMP1 is an inhibitory molecule that regulates matrix metalloproteinases (MMPs), and disintegrin-metalloproteinases (ADAMs and ADAMTSs) . In regulating MMPs, TIMP1 plays a crucial role in extracellular matrix (ECM) composition, wound healing, and pregnancy.The dysregulated activity of TIMP1 has been implicated in cancer. In pregnancy, TIMP1 plays a regulatory role in the process of implantation, particularly the cytotrophoblast invasion of the uterine endometrium. Additionally, it plays a role in regulating the transcriptional profile of fetal and placental tissues associated with the early stages of pregnancy. Studies attribute this role to a mechanism involving the chromatin structure at the TIMP1 promoter region, implicating new pharmaceutical possibilities for the therapeutic regulation of TIMP1. Accordingly, TIMP1 can be manipulated in vitro using techniques, like the TIMP1 knock-out. [Wiki]
UniProt
P01033
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for this recombinant TIMP1 antibody.
Clonality
Recombinant
Clone
TIMP1/1944R
Conjugation
Unconjugated
Field of Research
Cancer Biology
Purification
Protein A affinity chromatography
Dilution
ELISA: 2-4ug/ml (order BSA/azide-free format)
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the recombinant TIMP1 antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Tested Applications
ELISA
Host or Source
Rabbit
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Rabbit IgG, kappa

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