Recombinant CFTR Antibody

CAT: 0013-GTR18573445Size: 7 mLDry Ice: NoHazardous: No

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CAT#:0013-GTR18573445Size:7 mL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

CFTR functions as an ATP-gated anion channel, increasing the conductance for certain anions (e.g. Cl−) to flow down their electrochemical gradient. ATP-driven conformational changes in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient.[5] This in contrast to other ABC proteins, in which ATP-driven conformational changes fuel uphill substrate transport across cellular membranes. Essentially, CFTR is an ion channel that evolved as a 'broken' ABC transporter that leaks when in open conformation. CFTR is found in the epithelial cells of many organs including the lung, liver, pancreas, digestive tract, and the reproductive tract. [Wiki]

UniProt

P13569

Reactivity

Human

Immunogen

A recombinant human partial protein was used as the immunogen for this recombinant CFTR antibody.

Clonality

Recombinant

Clone

RCFTR/1342

Conjugation

Unconjugated

Field of Research

Cell Biology

Purification

Protein G affinity chromatography

Dilution

The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the recombinant CFTR antibody should be determined by the researcher. 1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Tested Applications

IHC-P

Host or Source

Mouse

Preservative

Prediluted in 1X PBS, 0.1 mg/ml rAlbumin, 0.05% sodium azide; For IHC use only

Isotype

Mouse IgG1, kappa

UniProtKB · P13569

Cystic fibrosis transmembrane conductance regulator

CFTR_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P13569
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CFTR
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: CFTR
EC number: —
Processing: —
Secondary accessions: Q20BG8, Q20BH2, Q2I0A1, Q2I102

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingChlorideNucleotide-binding

Cellular component

Cell membraneEndoplasmic reticulumEndosomeMembraneNucleus

Molecular function

Chloride channelIon channelIsomerase

Disease

Disease variant

PTM

GlycoproteinIsopeptide bondLipoproteinPalmitatePhosphoproteinUbl conjugation

Biological process

Ion transportTransport

Domain

RepeatTransmembraneTransmembrane helix

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