Recombinant vWF Antibody

CAT: 0013-GTR18573354Size: 7 mLDry Ice: NoHazardous: No

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CAT#:0013-GTR18573354Size:7 mL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Von Willebrand Factor (vWF) is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII, including cleavage of the propeptide and formation of N-terminal disulfide bonds. This antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposi's sarcoma and cardiac myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers although not all tumors of endothelial differentiation contain this antigen.

UniProt

P04275

Reactivity

Human

Immunogen

Amino acids 1815-1939 from the human protein were used as the immunogen for this recombinant vWF antibody.

Clonality

Recombinant

Clone

VWF/1859R

Conjugation

Unconjugated

Field of Research

Cardiovascular Research

Purification

Protein A affinity chromatography

Dilution

The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

The optimal dilution of the recombinant vWF antibody for each application should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Tested Applications

IHC-P

Host or Source

Rabbit

Preservative

Prediluted in 1X PBS, 0.1 mg/ml rAlbumin, 0.05% sodium azide; For IHC use only

Isotype

Rabbit IgG, kappa

UniProtKB · P04275

von Willebrand factor

VWF_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P04275
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: VWF
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: vWF
EC number: —
Processing: Precursor
Secondary accessions: Q8TCE8, Q99806

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Blood coagulationCell adhesionHemostasis

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoprotein

Disease

Disease variantvon Willebrand disease

Cellular component

Extracellular matrixSecreted

Domain

RepeatSignal

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