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PAX7 Antibody

CAT: 0013-GTR18572643Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18572643Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The Pax gene family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. In addition, the family is involved in a variety of signal transduction pathways in the adult organism. Mutations in the Pax family of proteins have been linked to disease and cancer in humans. Pax-7 is a protein specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization reveals that Pax-7 is also expressed in satellite cells residing in adult muscle. A chromosomal aberration in the gene encoding Pax-7 causes rhabdomyosarcoma 2 (RMS2) (also called alveolar rhabdomyosarcoma) .
UniProt
P23759
Reactivity
Human
Immunogen
Recombinant human PAX7 protein corresponding to amino acids 301-505 was used as the immunogen for this antibody.
Clonality
Monoclonal
Clone
PAX7/1187
Conjugation
Unconjugated
Field of Research
Stem Cell & Developmental Biology
Purification
Protein G affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT, Prediluted IHC only format: incubate for 30 min at RT (1)
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the PAX7 antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG1, kappa

UniProtKB · P23759

Paired box protein Pax-7

PAX7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P23759
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PAX7
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
E9PFV9, Q0VA99, Q2PJS5
Protein keywords

PTM

Acetylation

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Molecular function

Developmental proteinDNA-binding

Disease

Disease variantProto-oncogene

Domain

HomeoboxPaired box

Biological process

MyogenesisTranscriptionTranscription regulation

Cellular component

Nucleus

Technical term

Proteomics identificationReference proteome

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