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NGF Receptor Antibody

CAT: 0013-GTR18572626Size: 7 mLDry Ice: NoHazardous: No
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CAT#:0013-GTR18572626Size:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR) . NGF-receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGF is important for the development, differentiation, and survival of variety of neuronal and non-neuronal cells. Its action is mediated by binding two distinct receptors, the high affinity p140 and low affinity p75.
UniProt
P08138
Reactivity
Human
Immunogen
NGFR from A875 melanoma cells was used as the immunogen for the NGF Receptor antibody. Its epitope is within amino acids 1-160 of the extracellular domain of NGFR/NTR.
Clonality
Monoclonal
Clone
SPM299
Conjugation
Unconjugated
Field of Research
Neuroscience
Purification
Protein G affinity chromatography
Dilution
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the NGF Receptor antibody should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
Prediluted in 1X PBS, 0.1 mg/ml rAlbumin, 0.05% sodium azide; For IHC use only
Isotype
Mouse IgG1, kappa

UniProtKB · P08138

Tumor necrosis factor receptor superfamily member 16

TNR16_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08138
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NGFR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B2R961, B4E096
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisBiological rhythmsDifferentiationNeurogenesis

Cellular component

Cell membraneCell projectionCytoplasmMembraneSynapse

Molecular function

Developmental proteinReceptor

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

RepeatSignalTransmembraneTransmembrane helix

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