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EGF Receptor Antibody

CAT: 0013-GTR18571918Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18571918Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This antibody reacts with the extracellular domain of EGF receptor and blocks the EGF/TGFa-induced activation. It also blocks tumor growth in vivo. It is excellent for purification of EGF receptor.EGFR is type I receptor tyrosine kinase with sequence homology to ErbB2, -3 -4 or HER2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGFa), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin.
Reactivity
Human
Immunogen
Microsomes from A431 cells were used as the immunogen for this antibody.
Clonality
Monoclonal
Clone
B1D8
Conjugation
Unconjugated
Field of Research
Cancer Biology
Purification
Protein G purified monoclonal antibody
Dilution
Affinity purification (order BSA/sodium azide-free format for coupling), Blocks ligand-induced activation of EGFR, Inhibits proliferation of A431 cells (order BSA/azide-free format), Arrests tumor growth in vivo (order BSA/azide-free format), Immunoprecipitation: 1-2ug/500ug protein lysate, Flow cytometry: 0.5-1ug/10^6 cells
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.
Tested Applications
Blocking, FACS, IP, NeA, Purification
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2a, kappa

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