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SP100 Antibody

CAT: 0013-GTR18571688Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18571688Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The human SP100 gene encodes an autoantigen that co-localizes with PML and NDP52 in distinct nuclear domains, called nuclear dots (NDs) or ND10 nuclear bodies. Papova-, adeno-, and herpesviruses begin their transcription and DNA-replication at NDs, which play a role in autoimmunity, viral infections and in the etiology of acute promyelocytic leukemia. SP-100 is an interferon inducible protein that has two splice variants. One splice variant contains a highly conserved copy of the DNA-binding high mobility group 1 protein sequence, and thus represents a novel HMG-box protein. This alternatively spliced variant of SP-100 has a unique expression and localization pattern that is distinct from the SP-100 full-length protein. The SP100 protein is covalently modified by the small ubiquitin-related protein SUMO-1. SP-100 contains a functional nuclear localization signal and an ND-targeting region, which overlaps with the SP-100 homodimerization domain.
UniProt
P23497
Reactivity
Human
Immunogen
Recombinant full-length human SP100 protein was used as the immunogen for the SP100 antibody.
Clonality
Monoclonal
Clone
PCRP-SP100-1B9
Conjugation
Unconjugated
Purification
Protein A/G affinity
Dilution
ELISA (For coating, order BSA-free format), Western blot: 1-2ug/ml, Immunofluorescence: 0.5-2ug/ml, Immunoprecipitation: 1-2ug per 100-500ug of total protein (1ml of cell lysate), Flow cytometry: 0.5-2ug/million cells, Immunohistochemistry (FFPE) : 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the SP100 antibody should be determined by the researcher.
Tested Applications
ELISA, FACS, IF, IHC-P, IP, WB
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2b

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