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Recombinant MBP Antibody / Myelin Basic Protein

CAT: 0013-GTR18572079Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18572079Size:100 µg
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Description
Myelin basic protein (MBP) is the second most abundant protein in central nervous system (CNS) myelin: it comprises 30% of the total protein and about 10% of the dry weight of myelin. It is the only structural protein found so far to be essential for formation of CNS myelin, and has been called the executive molecule of myelin . MBP can interact with a number of polyanionic proteins including actin, tubulin, calmodulin, and clathrin, and negatively charged lipids, and acquires structure on binding to them. It may act as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. MBP may be applicable as a marker for oligodendrogliomas. Clone rMBP/9301 is used in a two-site ELISA with clone MBP/4273. Both are used interchangeably as capture and detection antibody.
UniProt
P02686
Reactivity
Human
Immunogen
A recombinant fragment (within amino acids 1-157) of human Myelin Basic Protein was used as the immunogen for the recombinant MBP antibody.
Clonality
Recombinant
Clone
RMBP/9301
Conjugation
Unconjugated
Field of Research
Neuroscience
Purification
Protein A/G affinity
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml, Western blot: 2-4ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the recombinant MBP antibody should be determined by the researcher.
Tested Applications
IHC-P, WB
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2b, kappa

UniProtKB · P02686

Myelin basic protein

MBP_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P02686
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MBP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MBP
EC number
—
Processing
—
Secondary accessions
A4FU54, A6NI84, A8MY86, A8MYL4, B3KY66, B7ZKS2, B7ZKS4, Q15337, Q15338, Q15339, Q15340, Q59GX3, Q65ZS4, Q6AI64, Q6FH37, Q6FI04, Q6PK23
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationCitrullinationMethylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Disease

Autoimmune encephalomyelitis

Cellular component

Cell membraneMembraneNucleus

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