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Recombinant MDM2 Antibody

CAT: 0013-GTR18571444Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18571444Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MDM2 is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53. It can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function.This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. Overexpression of MDM2 protein is detected in a variety of cancers.
UniProt
Q00987
Reactivity
Human
Immunogen
A recombinant human MDM2 protein fragment was used as the immunogen for the recombinant MDM2 antibody.
Clonality
Recombinant
Clone
RMDM2/9214
Conjugation
Unconjugated
Field of Research
Cell Biology
Purification
Protein A/G affinity
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the recombinant MDM2 antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2b, kappa

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