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CD162 Antibody / PSGL-1

CAT: 0013-GTR18571427-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18571427-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD162 glycoprotein functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response.
UniProt
Q14242
Reactivity
Human
Immunogen
Recombinant human PSGL-1 /CD162 protein was used as the immunogen for the CD162 antibody.
Clonality
Monoclonal
Clone
PSGL1/1567
Conjugation
Unconjugated
Field of Research
Immunology & Inflammation
Purification
Protein A/G affinity
Dilution
Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-3ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the CD162 antibody should be determined by the researcher.
Tested Applications
FACS, IF
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Isotype
Mouse IgM, kappa

UniProtKB · Q14242

P-selectin glycoprotein ligand 1

SELPL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q14242
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SELPLG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PSGL-1
EC number
—
Processing
Precursor
Secondary accessions
A8K2Y0, B4DQC3, B7Z5C7, J3KMX6, Q12775, Q6GTW7, Q8N7J7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesionHost-virus interaction

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinPhosphoproteinPyrrolidone carboxylic acidSulfation

Molecular function

Host cell receptor for virus entryReceptor

Cellular component

Membrane

Domain

RepeatSignalTransmembraneTransmembrane helix

Ligand

Sialic acid

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