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Recombinant Beta-2 Microglobulin Antibody

CAT: 0013-GTR18571360Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18571360Size:100 µg
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Description
Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alpha heavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alpha heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alpha heavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
UniProt
P61769
Reactivity
Human
Immunogen
Recombinant full-length human B2M protein was used as the immunogen for the recombinant Beta-2 Microglobulin antibody.
Clonality
Recombinant
Clone
RB2M/7279
Conjugation
Unconjugated
Purification
Protein A affinity
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the recombinant Beta-2 Microglobulin antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG1, kappa

UniProtKB · P61769

Beta-2-microglobulin

B2MG_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P61769
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
B2M
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
P01884, Q540F8, Q6IAT8, Q9UCK0, Q9UD48, Q9UDF4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Cellular component

AmyloidMHC ISecreted

Disease

AmyloidosisDisease variant

PTM

Disulfide bondGlycationGlycoproteinPyrrolidone carboxylic acid

Biological process

Immunity

Domain

Immunoglobulin domainSignal

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