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GRAMD4 Antibody

CAT: 0013-GTR18571281-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18571281-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The gene encoding GRAMD4 (GRAM domain-containing protein 4) maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. GRAMD4, also designated death-inducing protein (DIP), is a 578 amino acid mitochondrial membrane protein that acts as an essential mediator of the p53-independent E2F-1 death pathway, which is frequently found to be deregulated in several types of cancers. Overexpression of GRAMD4 results in a strong apoptotic response involving caspase-3 activation and cleavage of poly (ADP-ribose) -polymerase. GRAMD4 is expressed in lung and in primary lung squamous cell carcinoma (LSCC) and shows upregulation in mitochondria by E2F1 after addition of 4-hydroxytamoxifen. This evidence suggests that GRAMD4 may be a potential target for cancer therapies.
UniProt
Q6IC98
Reactivity
Human
Immunogen
Recombinant full-length human GRAMD4 protein was used as the immunogen for the GRAMD4 antibody.
Clonality
Monoclonal
Clone
PCRP-GRAMD4-1A10
Conjugation
Unconjugated
Field of Research
Cell Biology
Purification
Protein A/G affinity
Dilution
Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the GRAMD4 antibody should be determined by the researcher.
Tested Applications
FACS, IF
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Isotype
Mouse IgG1

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