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NKX2.8 Antibody

CAT: 0013-GTR18574808Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18574808Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects.
UniProt
O15522
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 10-123) was used as the immunogen for the NKX2.8 antibody.
Clonality
Monoclonal
Clone
NKX28/2547
Conjugation
Unconjugated
Field of Research
Stem Cell & Developmental Biology
Purification
Protein G affinity chromatography
Dilution
Western blot: 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the NKX2.8 antibody should be determined by the researcher.
Tested Applications
WB
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG1, kappa

UniProtKB · O15522

Homeobox protein Nkx-2.8

NKX28_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15522
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NKX2-8
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q8IUT7
Protein keywords

Molecular function

Developmental proteinDNA-binding

Domain

Homeobox

Cellular component

Nucleus

Technical term

Proteomics identificationReference proteome

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