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Recombinant MUC3 Antibody

CAT: 0013-GTR18575534Size: 7 mLDry Ice: NoHazardous: No
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CAT#:0013-GTR18575534Size:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
It recognizes a protein of HMW, identified as mucin 3 glycoprotein (MUC3) . Its epitope localizes between aa SITTTE. This MAb shows no cross-reaction with human milk fat globule membranes, MUC1, or MUC2. MUC3 is distributed in colon and rectum, and is also present to a lesser extent in breast, lung and salivary gland tissues. The Mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs) encoded by 60 base pairs (Mucin 1), 69 base pairs (Mucin 2) and 51 base pairs (Mucin 3) . The number of repeats is highly polymorphic and varies among different alleles. Mucin 1 proteins are expressed as type I membrane proteins in addition to secreted forms. Mucin 1 is aberrantly expressed in epithelial tumors including breast carcinomas. Mucin 2 coats the epithelia of the intestines and airways and is associated with colonic tumors. Mucin 3 is a major component of various mucus gels and is broadly expressed in normal and tumor cells.
UniProt
Q02505
Reactivity
Human
Immunogen
Amino acids (C-HSTPSFTSSITTTETTSHSTPSFTSSITTTETTS) which contains two of the MUC3 tandem repeats was used as the immunogen for the MUC3 antibody.
Clonality
Recombinant
Clone
MUC3/2992R
Conjugation
Unconjugated
Purification
Protein A affinity chromatography
Dilution
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the recombinant MUC3 antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Tested Applications
IHC-P
Host or Source
Rabbit
Preservative
Prediluted in 1X PBS, 0.1 mg/ml rAlbumin, 0.05% sodium azide; For IHC use only
Isotype
Rabbit IgG, kappa

UniProtKB · Q02505

Mucin-3A

MUC3A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q02505
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MUC3A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MUC-3A
EC number
—
Processing
Precursor
Secondary accessions
A6NP22, O14650, O14651, O43418, O43421, Q02506, Q6W763, Q9H3Q7, Q9UKW9, Q9UN93, Q9UN94, Q9UN95
Protein keywords

Coding sequence diversity

Alternative splicing

PTM

Disulfide bondGlycoprotein

Domain

EGF-like domainRepeatSignalTransmembraneTransmembrane helix

Cellular component

MembraneSecreted

Technical term

Proteomics identificationReference proteome

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