Products for Research Use Only
RegisterLogin

TRAF1 Antibody

CAT: 0013-GTR18574424Size: 7 mLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR18574424Size:7 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
This mAb recognizes a protein of 52kDa, which is identified as TNFR1 (TNFR-associated factor 1) . CD30-positive lymphoproliferations of the skin comprise 30% of all primary cutaneous T-cell lymphomas (CTCLs) . Besides borderline cases this group includes lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large T-cell lymphoma (cALCL) . Although the two entities overlap clinically, histopathologically, immunopathologically and genetically, they differ considerably in their prognosis. In particular, common feature of both cases is histologically the presence of atypical lymphoid CD30-positive T blasts and genetically a clonal T-cell-receptor rearrangement. However, both cases differ considerably in their clinical course: Lesions of LyP regress spontaneously, whereas those of cALCL persist and may progress and spread. Moreover, LyP patients do not benefit from an aggressive radio- and/or chemotherapeutic approach, in contrast to patients with cALCL. Besides, LyP and cALCL differ strongly in the expression of TRAF1 (tumor necrosis factor receptor (TNFR) -associated factor 1), a component of TNFR signaling: Whereas tumor cells of most LyP cases (ca. 84%) show a strong TRAF1 expression, tumor cells of cALCL reveal TRAF1 expression in only a few cases (ca. 7%) . Antibody to TRAF1 is highly useful for the differentiation of LyP and cALCL in patients with cutaneous CD30-positive lymphoproliferations.
UniProt
Q13077
Reactivity
Human
Immunogen
A portion of amino acids 73-219 from the human protein was used as the immunogen for the TRAF1 antibody.
Clonality
Monoclonal
Clone
TRAF1/2770
Conjugation
Unconjugated
Field of Research
Cell Biology
Purification
Protein G affinity chromatography
Dilution
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the TRAF1 antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
Prediluted in 1X PBS, 0.1 mg/ml rAlbumin, 0.05% sodium azide; For IHC use only
Isotype
Mouse IgG1, kappa

Related Products

CatalogName
GTR18195377TRAF1 Polyclonal Antibody
GTR18297804-01TRAF1 polyclonal antibody
GTR18281012TRAF1 Conjugated Antibody
GTR18914073TRAF1 Peptide
GTR18904507-01TRAF1 peptide
GTR18108387-01TRAF1 Rabbit Polyclonal Antibody
GTR17722646-01TRAF1 Rabbit Polyclonal Antibody
GTR17693869TRAF1 Rabbit Polyclonal Antibody
GTR18315166-01TRAF1 Rabbit Polyclonal Antibody
GTR18030881-01TRAF1 Rabbit Polyclonal Antibody

Alternative Products

CatalogName
FNab08916TRAF1 antibody

Popular Products