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CD127 Antibody / IL7R

CAT: 0013-GTR18574328Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18574328Size:100 µg
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Description
The protein encoded by this gene is a receptor for interleukin 7 (IL7) . The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V (D) J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID) .
UniProt
P16871
Reactivity
Human
Immunogen
A portion of amino acids 21-236 from the human protein was used as the immunogen for the CD127 antibody.
Clonality
Monoclonal
Clone
IL7R/2751
Conjugation
Unconjugated
Field of Research
Immunology & Inflammation
Purification
Protein G affinity chromatography
Dilution
ELISA: order BSA/sodium azide-free format for coating, Western blot: 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the CD127 antibody should be determined by the researcher.
Tested Applications
ELISA, WB
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2c, kappa

UniProtKB · P16871

Interleukin-7 receptor subunit alpha

IL7RA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P16871
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IL7R
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IL-7 receptor subunit alpha, IL-7R subunit alpha, IL-7R-alpha, IL-7RA
EC number
—
Processing
Precursor
Secondary accessions
B2RCS6, B4DVT1, Q05CU8, Q6NSP4, Q6NWM0, Q6NWM1, Q6NWM2, Q6NWM3, Q6SV45, Q9UPC1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

Disease

Disease variantSCID

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Molecular function

Receptor

Domain

SignalTransmembraneTransmembrane helix

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